To keep up with the abundance of papers that catch our eye, we discuss multiple papers at each journal club, only one paper is discussed in-depth with highlights from the others.
The lists below are a highlight of what caught our attention and give some insight into the broad interests of the lab.
10 June 2025
A preoptic neuronal population controls fever and appetite during sickness. Osterhout et al. Nature 2022
Estradial mediates astrocyte-neuron communication in the hippocampus. Goenaga et al. Molecular Neurobiology 2025
Bioactive ketamine metabolite exerts in vivo neuroplastic effects to improve hippocampal function in a treatment-resistant depression model. Riggs et al. Cell Reports 2025
Orexin neurons inhibit sleep to promote arousal. De Luca et al. Nature Communications 2022
13 May 2025
A high-performance fluorescent sensor spatiotemporally reveals cell-type specific regulation of intracellular adenosine in vivo. Wei et al. Nature Communications 2025
Astrocyte Modulation of Synaptic Plasticity Mediated by Activity-Dependent Sonic Hedgehog Signaling. Duc Le et al. J Neuroscience 2025
Region-specific nucleus accumbens dopamine signals encode distinct aspects of avoidance learning. Lopez et al. Current Biology 2025
Amygdala ensembles encode behavioral states. Gründemann et al. Science 2019
8 April 2025
Stress-induced dysfunction of neurovascular astrocytes in the prefrontal cortex contributes to sex-dependent deficits in cognition and behaviour. Bollinger et al. Molecular Psychiatry 2025.
Reviving-like prosocial behaviour in response to unconscious or dead conspecifics in rodents. Sun et al. Science 2025
Distinct temporal integration of noradrenaline signalling by astrocytic second messengers during vigilance. Oe et al. Nature Communications 2020
Astrocytic cannabinoid receptor 1 promotes resilience by dampening stress-induced blood-brain barrier alterations. Dudek et al. Nature Neuroscience 2025
Astrocyte reactivity and inflammation-induced depression-like behaviors are regulated by Orai1 calcium channels. Novakovic et al. Nature Communications 2023
11 February 2025
Understanding the neural code of stress to control anhedonia. Xia et al. Nature 2025
Stress-activated neuronal ensemble in the supramammillary nucleus stores anxiety but not memory. Zhang et al. bioRxiv 2025
Ketamine induces plasticity in a norepinephrine-astroglial circuit to promote behavioral perseverance. Duque et al. Neuron 2025
Treadmill exercise prevents stress-induced anxiety-like behaviors via enhancing the excitatory input from the primary motor cortex to the thalamocortical circuit. Luo et al. Nat Comms 2025
Perineuronal Nets on CA2 Pyramidal Cells and Parvalbumin-Expressing Cells Differentially Regulate Hippocampal-Dependent Memory. Alexander et al. J Neurosci 2025
14 January 2025
Oxytocin Gαi signaling-induced amygdala astrocytes processes retraction shapes behavioral stress response. Baudon et al. bioRxiv 2024
A sensitive period for the development of episodic-like memory in mice. Ramsaran et al. bioRxiv 2024
Astrocytes release ATP/ADP and glutamate in flashes via vesicular exocytosis. Li et al. Molecular Psychiatry 2024
OXTR-mediated signaling in astrocytes contributes to anxiolysis. Meinung et al. Molecular Psychiatry 2024
Astrocytic GLUT1 reduction paradoxically improves central and peripheral glucose homeostasis. Ardanaz et al. Science Advances 2024
12 November 2024
Olfactory bulb astrocytes link social transmission of stress to cognitive adaptation in male mice. Gómez-Sotres et al. Nature Communications 2024
An anterior hypothalamic circuit gates stress vulnerability. Pennington et al. bioRxiv 2024
Brain region–specific action of ketamine as a rapid antidepressant. Chen et al. Science 2024
Pyramidal cell types and 5-HT2A receptors are essential for psilocybin’s lasting drug action. Shao et al. bioRxiv 2024
Neuron-astrocyte Coupling in Lateral Habenula Mediates Depressive-like Behaviors. Xin et al. bioRxiv 2024
Glucocorticoid regulation of ATP release from spinal astrocytes underlies diurnal exacerbation of neuropathic mechanical allodynia. Koyanagi et al. Nature Communications 2016
Astrocytic BDNF signaling within the ventromedial hypothalamus regulates energy homeostasis. Ameroso et al. Nature Metabolism 2022
Learning-associated astrocyte ensembles regulate memory recall. Williamson et al. Nature 2024
8 October 2024
Acetate enables metabolic fitness and cognitive performance during sleep disruption. He et al. Cell Metabolism 2024
A hippocampal astrocytic sequence emerges during learning and memory. Senne et al. BioRxiv 2024
Adenosine signalling to astrocytes coordinates brain metabolism and function. Theparambil et al. Nature 2024
Dysfunctional serotonergic neuron-astrocyte signaling in depressive-like states. González-Arias et al. Molecular Psychiatry 2024
Feedforward inhibition of stress by brainstem neuropeptide Y neurons. Zhang et al. Nature Communications 2024
Astrocytic metabolic control of orexinergic activity in the lateral hypothalamus regulates sleep and wake architecture. Braga et al. Nature Communications 2024
10 September 2024
Astrocyte Gi-GPCR signaling corrects compulsive-like grooming and anxiety-related behaviors in Sapap3 knockout mice. Soto et al. Neuron 2024
GEARBOCS: An Adeno Associated Virus Tool for In Vivo Gene Editing in Astrocytes. Bindu et al. BioRxiv 2023
Serotonin release in the habenula during emotional contagion promotes resilience. Mondolini et al. Science 2024
Divergent recruitment of developmentally defined neuronal ensembles supports memory dynamics. Kveim et al. Science 2024
Controlling Visually Guided Behavior by Holographic Recalling of Cortical Ensembles. Carrillo-Reid et al. Cell 2019
Astrocytes in the Ventral Hippocampus Bidirectionally Regulate Innate and Stress-Induced Anxiety-Like Behaviors in Male Mice. Li et al Advanced Sciences 2024
Ketamine ameliorates post-traumatic social avoidance by erasing the traumatic memory encoded in VTA-innervated BLA engram cells. Li et al. Neuron 2024